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Table 1 Details of opioid drugs in common use in dogs and cats

From: Anaesthesia for the geriatric dog and cat

Drug

Analgesic efficacy

Dose and route

Duration of action

Major drawbacks

Morphine

Excellent

0.1-0.2 mg/kg IM

Up to 4 hours

May cause vomiting

Pethidine

Good

3-5 mg/kg

IM

Up to 2 hours

Histamine release if administered

IV

Buprenorphine

Moderate - good

10-20 μg/kg IM

Up to 6 hours

May prevent action of morphine

Butorphanol

Poor

0.2-0.4 mg/kg IM

Up to 1.5 hours

Weak analgesic