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Table 2 Amino acid substitutions in gyrA and parC and antimicrobial resistance profiles in 51 Salmonella isolates from poultry slaughterhouses by nalidixic acid resistance

From: Amino acid substitutions in gyrA and parC associated with quinolone resistance in nalidixic acid-resistant Salmonella isolates

Resistance pattern of nalidixic acid Serovars (No. of isolates ) Amino acid substitution in* MICs(mg/l) Antimicrobial resistance profiles§
GyrA ParC Na Cip
Resistant Enteritis (18) D87G WT 512 0.25 AmCSTe (1), AmS (2), STe (1)
512 0.5 AmCfS (2), AmS (2)
D87Y WT >512 0.5 - (8)
D87N WT >512 0.5 AmCfCzGmKCazCtxFepSTe (1), - (1)
Montevideo (5) D87G WT >512 0.25 - (2)
512 0.25 - (3)
Senftenberg (2) D87N WT 512 0.5 - (1)
D87G WT 512 0.25 - (1)
Newport (2) D87Y WT 512 0.5 - (1)
>512 0.5 - (1)
Susceptible Typhimurium (8) WT WT 8 <0.0625 - (6)
8 0.25 - (1)
16 <0.0625 STe (1)
Montevideo (4) WT WT 4 <0.0625 GmK (2), - (2)
Hadar (5) WT WT 4 <0.0625 AmCfCzSTe (1)
8 <0.0625 AmCfCzKSTe (1), STe (2), KS (1)
Ohio (3) WT WT 4 <0.0625 STe (1), - (2)
London (3) WT WT 4 <0.0625 AmCfSTe (1)
8 <0.0625 - (2)
  Hogton (1) WT WT 8 <0.0625 KSTe (1)
  1. *D, aspartic acid; G, glycine; N, asparagine; Y, tyrosine.
  2. WT, wild type.
  3. Cip, ciprofloxacin; Na, nalidixic acid.
  4. §Am, ampicillin; C, chloramphenicol; Caz, ceftazidime; Cf, cephalothin; Cz, cefazolin; Ctx, cefotaxime; Fep, cefepime; Gm, gentamicin; K, kanamycin; S, streptomycin; Te, tetracycline.