Table 1 The results of immunohistochemical examination in studied dogs

DES intensity; median (range)

1 (1–2)¹

2 (1–3)

2 (2–3)¹

¹ 0.006

DES %; average ± SD

85.8 ± 10.9

84.8 ± 9.3

82.2 ± 8.6

DES Remmele; median (range)

4 (3–8)^{1, 2}

6 (4–9) ¹

7 (6–10)²

¹ 0.03

² 0.001

DES desmosomes; median (range)

0 (0–3)¹

2 (0–3)

2 (1–3)¹

¹ 0.02

VIM intensity; median (range)

3 (2–3)

3 (2–3)

2 (2–3)

VIM %; average ± SD

15.3 ± 6.3^1,2

10.99 ± 5.7¹

10.5 ± 1.97²

¹ 0.03

²0.02

VIM Remmele; median (range)

4 (2–6)

3 (2–6)

4 (3–5)

PER intensity; median (range)

1 (0–2)

1 (1–2)

1 (1–1)

PER %; average ± SD

27.96 ± 27.6¹

46.4 ± 28.5

67.76 ± 9.7¹

¹ 0.03

PER Remmele; median (range)

2 (0–3)

3 (1–4)

3 (3–3)

CAS intensity; median (range)

1 (0–2)

1 (1–2)

1 (1–2)

CAS %; average ± SD

46.9 ± 25.1^1,2

73.6 ± 24.9¹

84.6 ± 8.9²

¹ 0.01

² 0.01

CAS Remmele; median (range)

3 (1–4)^1,2

4 (1–7)¹

4 (3–9)²

¹ 0.01

² 0.01