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Table 4 Heart rate, mean arterial blood pressure, respiratory rate, end-tidal carbon dioxide, and end-tidal isoflurane concentration

From: Effects of midazolam on cardiovascular responses and isoflurane requirement during elective ovariohysterectomy in dogs

Para-meter

Group

Period 1

Period 2

Period 3

Period 4

Period 5

HR

M

97.0 ± 12.3

104 ± 15.2

106 ± 11.9

105 ± 11.4

114 ± 15.9

P

101 ± 18.9

99 ± 14.2

105 ± 12.1

106 ± 14.5

119 ± 15.8

% change in HR from baseline (%)

M

N/A

9.3 ± 17.3

11.2 ± 17.8

9.9 ± 20.9

18.1 ± 23.4

P

N/A

−1.5 ± 12.6

4.7 ± 20.5

5.1 ± 27.0

19.6 ± 31.1

MAP (mmHg)

M

63.0 ± 6.7

72.0 ± 11.0

89.3 ± 9.5

86.6 ± 10.6

82.1 ± 13.2

P

72.0 ± 10.1

81.1 ± 10.6

97.5 ± 12.5

90.8 ± 14.2

89.9 ± 10.7

% change in MAP from baseline (%)

M

N/A

11.0 ± 20.4

40.8 ± 18.4

39.0 ± 23.1

30.8 ± 23.9

P

N/A

16.6 ± 17.2

38.2 ± 20.3

26.8 ± 19.8

27.9 ± 21.4

f R

M

16.0 ± 6.5

17.1 ± 7.8

13.1 ± 5.3

13.1 ± 5.1

14.7 ± 5.8

P

19.0 ± 9.9

17.8 ± 10.8

17.5 ± 5.8

14.7 ± 6.0

15.3 ± 6.7

PE’CO2 (kPa)

M

5.11 ± 0.41

5.42 ± 0.46

6.19 ± 0.56

5.88 ± 0.36

5.66 ± 0.51

P

5.35 ± 0.45

5.57 ± 0.56

5.91 ± 0.72

5.86 ± 0.7

5.76 ± 0.62

FE’Iso (%)

M

1.03 ± 0.14

1.15 ± 0.11

1.2 ± 0.17*

1.22 ± 0.2*

1.23 ± 0.1*

P

1.05 ± 0.11

1.16 ± 0.11

1.35 ± 0.15

1.43 ± 0.16

1.42 ± 0.19

Difference FE’Iso (%)

M/P

9.1

8.3

14.3

14.3

14.3

  1. Mean values for heart rate (HR), mean arterial blood pressure (MAP), end-tidal isoflurane concentration (FE’Iso); respiratory rate (fR); and end-tidal carbon dioxide (PE’CO2), and difference between groups in FE’Iso expressed in percent (% difference FE’Iso) for group P and group M for each time period (1–5). M/P, Midazolam/Placebo; %, percentage; Group M: midazolam (0.25 mg kg− 1), group P: Hartmann’s solution (0.125 ml kg− 1). Period 1 (baseline): time in operating room until start of surgery; Period 2: start of surgery to start of ovarian manipulation; Period 3: manipulation of the ovaries; Period 4: manipulation of the uterus; and Period 5: abdominal closure. N/A, not applicable. Data presented as mean ± standard deviation. *Statistical significance (p < 0.05)