Para-meter | Group | Period 1 | Period 2 | Period 3 | Period 4 | Period 5 |
---|---|---|---|---|---|---|
HR | M | 97.0 ± 12.3 | 104 ± 15.2 | 106 ± 11.9 | 105 ± 11.4 | 114 ± 15.9 |
P | 101 ± 18.9 | 99 ± 14.2 | 105 ± 12.1 | 106 ± 14.5 | 119 ± 15.8 | |
% change in HR from baseline (%) | M | N/A | 9.3 ± 17.3 | 11.2 ± 17.8 | 9.9 ± 20.9 | 18.1 ± 23.4 |
P | N/A | −1.5 ± 12.6 | 4.7 ± 20.5 | 5.1 ± 27.0 | 19.6 ± 31.1 | |
MAP (mmHg) | M | 63.0 ± 6.7 | 72.0 ± 11.0 | 89.3 ± 9.5 | 86.6 ± 10.6 | 82.1 ± 13.2 |
P | 72.0 ± 10.1 | 81.1 ± 10.6 | 97.5 ± 12.5 | 90.8 ± 14.2 | 89.9 ± 10.7 | |
% change in MAP from baseline (%) | M | N/A | 11.0 ± 20.4 | 40.8 ± 18.4 | 39.0 ± 23.1 | 30.8 ± 23.9 |
P | N/A | 16.6 ± 17.2 | 38.2 ± 20.3 | 26.8 ± 19.8 | 27.9 ± 21.4 | |
f R | M | 16.0 ± 6.5 | 17.1 ± 7.8 | 13.1 ± 5.3 | 13.1 ± 5.1 | 14.7 ± 5.8 |
P | 19.0 ± 9.9 | 17.8 ± 10.8 | 17.5 ± 5.8 | 14.7 ± 6.0 | 15.3 ± 6.7 | |
PE’CO2 (kPa) | M | 5.11 ± 0.41 | 5.42 ± 0.46 | 6.19 ± 0.56 | 5.88 ± 0.36 | 5.66 ± 0.51 |
P | 5.35 ± 0.45 | 5.57 ± 0.56 | 5.91 ± 0.72 | 5.86 ± 0.7 | 5.76 ± 0.62 | |
FE’Iso (%) | M | 1.03 ± 0.14 | 1.15 ± 0.11 | 1.2 ± 0.17* | 1.22 ± 0.2* | 1.23 ± 0.1* |
P | 1.05 ± 0.11 | 1.16 ± 0.11 | 1.35 ± 0.15 | 1.43 ± 0.16 | 1.42 ± 0.19 | |
Difference FE’Iso (%) | M/P | 9.1 | 8.3 | 14.3 | 14.3 | 14.3 |