Table 1 Pharmacokinetic parameters of tamoxifen after single oral administration (0.25 mg/kg) in six adult healthy horses
From: Tamoxifen in horses: pharmacokinetics and safety study
Animal | Mean | SD | ||||||
|---|---|---|---|---|---|---|---|---|
1 | 2 | 3 | 4 | 5 | 6 | |||
AUC 0-∞ (pg-mL/min) | 5172.6 | 4069.4 | 4689.7 | 8974.0 | 4775.2 | 4624.9 | 5384.3 | 1793.9 |
Cmax (pg/mL) | 5.7 | 3.3 | 5.5 | 9.6 | 7.4 | 5 | 6.1 | 2.2 |
Tmax (h) | 1 | 4 | 4 | 6 | 2 | 1 | 3.0 | 2.0 |
t1/2E (h) | 10.24 | 13.53 | 14.35 | 5.35 | 7.13 | 12.5 | 10.5 | 3.6 |