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Table 2 Pharmacokinetic parameters of tamoxifen metabolites (N-DMT, 4-OH TAM, and EDF) after single oral administration of tamoxifen (0.25mg/kg) in adult healthy horses (n = 6)

From: Tamoxifen in horses: pharmacokinetics and safety study

  Metabolite
4-OH TAM EDF N-DMT
AUC 0-∞ (pg-mL/min) 951.1 ± 461.9 249.1 ± 238.3 131.7 ± 107.6
Cmax (pg/mL) 1.0 ± 0.6 0.5 ± 0.4 0.2 ± 0.1
Tmax (h) 4.1 ± 4.2 3.0 ± 3.5 8.0 ± 8.8
t1/2E (h) 9.8 ± 3.7 ND ND