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Table 2 Pharmacokinetic parameters of tamoxifen metabolites (N-DMT, 4-OH TAM, and EDF) after single oral administration of tamoxifen (0.25mg/kg) in adult healthy horses (n = 6)

From: Tamoxifen in horses: pharmacokinetics and safety study

 

Metabolite

4-OH TAM

EDF

N-DMT

AUC 0-∞ (pg-mL/min)

951.1 ± 461.9

249.1 ± 238.3

131.7 ± 107.6

Cmax (pg/mL)

1.0 ± 0.6

0.5 ± 0.4

0.2 ± 0.1

Tmax (h)

4.1 ± 4.2

3.0 ± 3.5

8.0 ± 8.8

t1/2E (h)

9.8 ± 3.7

ND

ND