Table 5 Leukogram values before (Control) and after 4 (S1), 8 (S2), 11 (S3), and 15 (S4) days of treatment with tamoxifen (0.25 mg/kg, PO q 24 h for 7 days) in healthy adult horses (n = 20)
From: Tamoxifen in horses: pharmacokinetics and safety study
Sample | Control | S1 | S2 | S3 | S4 | Reference Range |
|---|---|---|---|---|---|---|
Parameter | Mean ± SD | |||||
Leukocytes | 9443 ± 2595 | 9360 ± 2201 | 9310 ± 1958 | 8990 ± 1539 | 9225 ± 1761 | 7200–14,400 cel/μL |
Basophils | 46 ± 63.1 | 29 ± 71.85 | 26 ± 40.27 | 39 ± 50.92 | 54 ± 65.98 | 0–300 cel/μL |
Eosinophils | 467 ± 315.22 | 347 ± 275.49 | 406 ± 269.58 | 370 ± 328.23 | 259 ± 214.02 | 100–800 cel/μL |
Neutrophils | 4923 ± 1226 | 5232 ± 1341 | 5164 ± 1208 | 4862 ± 948.43 | 5108 ± 1388 | 2200–6100 cel/μL |
Band neutrophils | 0 ± 0 | 4 ± 16.77 | 0 ± 0 | 5 ± 21.24 | 0 ± 0 | 0–200 cel/μL |
Juvenile neutrophils | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 cel/μL |
Lymphocytes | 3395 ± 1169 | 3433 ± 1343 | 3406 ± 1455 | 3482 ± 1042 | 3475 ± 1455 | 1500–6500 cel/μL |
Monocytes | 202 ± 94.16 | 215 ± 116.37 | 151 ± 112.77 | 232 ± 159.13 | 211 ± 159.32 | 0–600 cel/μL |