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Fig. 2 | Irish Veterinary Journal

Fig. 2

From: Sporadic worldwide “clusters” of feed driven Zilpaterol identifications in racing horses: a review and analysis

Fig. 2

Mean urinary concentrations of Zilpaterol post 0.17 mg/kg (~ 70 mg/horse) PO., replotted from Shelver et al [10]. The individual horses are represented by the teal, orange, and grey lines, and symbols. Mean values of the three horse data set are represented by the yellow circles and dashed line, with standard deviation of the groups at each timepoint represented by the black bars. The dark blue circles represent our pharmacokinetic model, calculated by curve stripping of the mean dataset to determine a multi-exponential decay model showing biphasic elimination. The first phase has a calculated half-life of 13.2 h, while the much slower terminal phase has a calculated half-life of 120.7 h, with the transition between these domains at approximately 6 days post treatment

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