Selective breeding can contribute to bovine tuberculosis control and eradication

Table 1 Genes associated with host resistance to bovine tuberculosis in different research studies in the past 10 years demonstrate the polygenic nature of the trait

Reference	[28]	[16]	[29]	[33]	[30]	[34]	[35]	[18]	[32]	[15]	[31]	[36]	[19]	[37]	[38]
Year	2012	2014	2015	2015	2016	2016	2017	2017	2017	2019	2019	2020	2020	2020	2021
Country^a, Breed^b	IE, HO	IE, HO	ET, HAX	TW, HO	IE, HO	TW, HO	CN, HO	UK, HO	UK, HO	IE. ML1	MX, HO	IN, MLX	CM, FX	UK/PK, ML2	CN, HO
No. animals	986	1,151	502	150	841	164	232	804	1,966	14,778	375	245	212	45	283
Approach^c	GWAS	GWAS, RHM	GWAS	SCG	GWAS	SCG	SCG	GWAS, RHM	RHM	GWAS	GWAS	SCG	GWAS	SCG	SCG
Chromosome
1					KALRN						CD80, TIGIT, NAALADL2
2		MYO3B		SLC11A1			SLC11A1	PARD3B			DNER			SLC11A1
3											CTSS, FCGR1A, TRIM33
4					DPP6
5											CD163
6			TLR1, TLR6, TLR10, RHOH							ANTXR2		TLR1
10					AP3B1					JMY
13		PTPRT									MACROD2, KIF16B
15										OR52E5, ENSBTAG00000023125, ENSBTAG00000047246, ENSBTAG00000048223, ENSBTAG00000023912
16										SRGAP2, RASSF5
17										CLGN
19															NOS2A
22	SLC6A6								RAF1, MKRN2, MKRN2OS, TSEN2, PPARG, MIR2373
23					FKBP5	TNFα		RNF144B	LRRC1, LOC104975626, KLHL31, GCLC, DSB, BOLA-DYA, BOLA-DYB, BOLA-DOB, LOC100140517, MLIP, LOC104975626	RCAN2	HFE	TNFα
25											IL21R
29											ANO9, SIGIRR		PICALM

^aCountry of study: IE Ireland, ET Ethiopia, TW Taiwan, CN China, UK United Kingdom, MX Mexico, IN India, CM Cameroon, PK Pakistan
^bBovine breed of study: HO Holstein, HAX HO x Arsi Zebu cross, ML1 Multiple beef and dairy breeds, MLX Multiple indigenous breeds and crosses, FX Fulani and crosses, ML2 HO, Brown Swiss, Sahiwal
^cData analysis method: GWAS Genome-Wide Association Study, RHM Regional Heritability Mapping, SCG Single Candidate Gene

ISSN: 2046-0481