Table 4 Erythrogram values before (Control) and after 4 (S1), 8 (S2), 11 (S3), and 15 (S4) days of treatment with tamoxifen (0.25 mg/kg, PO q 24 h for 7 days) in healthy adult horses (n = 20)
From: Tamoxifen in horses: pharmacokinetics and safety study
Sample | Control | S1 | S2 | S3 | S4 | Reference Range |
|---|---|---|---|---|---|---|
Parameter | Mean ± SD | |||||
Erythrocyte | 7.71 ± 1.21 | 7.44 ± 1.03 | 7.49 ± 1.03 | 7.42 ± 0.94 | 7.32 ± 0.97 | 4.9–8.5 × 10^6 μL |
Hematocrit | 36 ± 0.05 | 36 ± 0.05 | 36 ± 0.05 | 36 ± 0.05 | 35 ± 0.04 | 27–42% |
Hemoglobin | 123 ± 19.53 | 120 ± 15.41 | 121 ± 16.48 | 119 ± 14.45 | 117 ± 14.15 | 94–147 g/L |
MCV | 45 ± 10.42 | 47 ± 2.15 | 48 ± 2.27 | 46 ± 11.80 | 47 ± 2.15 | 42–62 fL |
MCHC | 338 ± 21.12 | 339 ± 13.60 | 341 ± 25.55 | 316 ± 80.45 | 340 ± 12.60 | 320–380 g/L |
Immature Eryth. | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0% |
Platelets | 152 ± 41.2 | 163 ± 48.8 | 159 ± 45.4 | 150 ± 46.8 | 153 ± 55.3 | 90-210 × 103/ μL |
Proteins | 71 ± 4.03 | 72 ± 6.64 | 74 ± 5.76 | 72 ± 4.77 | 74 ± 3.85 | 68–84 g/L |
Fibrinogen | 3 ± 1.10 | 3 ± 2.90 | 3 ± 2.18 | 3 ± 0.81 | 3 ± 2.06 | < 5 g/L |