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Table 6 Serum biochemistry before (Control) and after 4 (S1), 8 (S2), 11 (S3), and 15 (S4) days of treatment with tamoxifen (0.25 mg/kg, PO q 24 h for 7 days) in healthy adult horses (n = 20)

From: Tamoxifen in horses: pharmacokinetics and safety study

Sample Control S1 S2 S3 S4 Reference Range
Parameter Mean ± SD
Albumin 38 ± 4.27 38 ± 3.18 37 ± 5.99 38 ± 4.48 40 ± 5.61 26–38 g/L
AST 259 ± 97.57 243 ± 111.91 258 ± 138.37 272 ± 162.77 273 ± 96.96 140–480 U/L
Creatinine 96 ± 14.70 93 ± 79.17 102 ± 22.42 104 ± 31.86 98 ± 18.36 85–115 μmol/L
CK 332 ± 154.35 384 ± 306.83 263 ± 161.07 297 ± 166.16 276 ± 160.63 40–140 U/L
GGT 43 ± 43.03 40 ± 41.09 30 ± 14.08 32 ± 14.46 32 ± 20.73 12–62 U/L
SAP 585 ± 240.47 528 ± 244.99 549 ± 217.90 548 ± 266.68 557 ± 250.14 460-1060 U/L
LDH 621 ± 283.36 692 ± 192.79 659 ± 125.18 694 ± 121.91 663 ± 159.41 200–700 U/L
Total Proteins 74 ± 6.73 74 ± 5.66 76 ± 7.35 74 ± 6.52 77 ± 4.45 68–84 g/L
Urea 6.7 ± 1.39 7.4 ± 2.05 7.1 ± 1.24 7.2 ± 1.41 8.0 ± 2.16 3.6–8.8 mmol/L
Inorg. Phosphate 0.8 ± 0.28 0.8 ± 0.19 0.8 ± 0.23 0.9 ± 0.14 0.8 ± 0.28 0.9–1.5 mmol/L
Calcium 2.89 ± 0.23 2.92 ± 0.18 2.99 ± 0.27 2.85 ± 0.34 2.99 ± 0.21 2.49–3.21 mmol/L