Table 6 Serum biochemistry before (Control) and after 4 (S1), 8 (S2), 11 (S3), and 15 (S4) days of treatment with tamoxifen (0.25 mg/kg, PO q 24 h for 7 days) in healthy adult horses (n = 20)
From: Tamoxifen in horses: pharmacokinetics and safety study
Sample | Control | S1 | S2 | S3 | S4 | Reference Range |
|---|---|---|---|---|---|---|
Parameter | Mean ± SD | |||||
Albumin | 38 ± 4.27 | 38 ± 3.18 | 37 ± 5.99 | 38 ± 4.48 | 40 ± 5.61 | 26–38 g/L |
AST | 259 ± 97.57 | 243 ± 111.91 | 258 ± 138.37 | 272 ± 162.77 | 273 ± 96.96 | 140–480 U/L |
Creatinine | 96 ± 14.70 | 93 ± 79.17 | 102 ± 22.42 | 104 ± 31.86 | 98 ± 18.36 | 85–115 μmol/L |
CK | 332 ± 154.35 | 384 ± 306.83 | 263 ± 161.07 | 297 ± 166.16 | 276 ± 160.63 | 40–140 U/L |
GGT | 43 ± 43.03 | 40 ± 41.09 | 30 ± 14.08 | 32 ± 14.46 | 32 ± 20.73 | 12–62 U/L |
SAP | 585 ± 240.47 | 528 ± 244.99 | 549 ± 217.90 | 548 ± 266.68 | 557 ± 250.14 | 460-1060 U/L |
LDH | 621 ± 283.36 | 692 ± 192.79 | 659 ± 125.18 | 694 ± 121.91 | 663 ± 159.41 | 200–700 U/L |
Total Proteins | 74 ± 6.73 | 74 ± 5.66 | 76 ± 7.35 | 74 ± 6.52 | 77 ± 4.45 | 68–84 g/L |
Urea | 6.7 ± 1.39 | 7.4 ± 2.05 | 7.1 ± 1.24 | 7.2 ± 1.41 | 8.0 ± 2.16 | 3.6–8.8 mmol/L |
Inorg. Phosphate | 0.8 ± 0.28 | 0.8 ± 0.19 | 0.8 ± 0.23 | 0.9 ± 0.14 | 0.8 ± 0.28 | 0.9–1.5 mmol/L |
Calcium | 2.89 ± 0.23 | 2.92 ± 0.18 | 2.99 ± 0.27 | 2.85 ± 0.34 | 2.99 ± 0.21 | 2.49–3.21 mmol/L |